Esomeprazole vs omeprazole which is better

There was less interpatient variability in AUC and gastric pH data with esomeprazole than with omeprazole. The gastric pH data from this study show a clear benefit with esomeprazole versus omeprazole.

Gastric pH is an intermediate endpoint, however, and is meaningless unless it correlates with improved clinical outcomes. As yet unpublished clinical trial results suggest that pH control will correlate with clinical improvements.

Interpatient variability is a problem with PPIs because of unpredictable variation in cytochrome P 2C19, which mediates the major metabolic pathway for this class. Because esomeprazole is less dependent on this pathway, it should offer a more predictable therapeutic advantage in all patients.

Although very similar in many aspects, esomeprazole may be a more effective treatment option in the management of gastro-intestinal reflux related conditions as confirmed by a number of studies. Although esomeprazole is more expensive to the NHS as compared to omeprazole, the use of esomeprazole should be promoted in patients who failed to respond to other PPIs. Patients need to remember that self-treatment with over the counter esomeprazole or omeprazole is limited usually to two weeks.

Patients who have not achieved symptom relief during that time or who need ongoing treatment of over two weeks need to speak to their GP. Dent Review article: pharmacology of esomeprazole and comparisons with omeprazole. Esomeprazole: a clinical review. Am J Health Syst Pharm. PMID: Jones R, Patrikios T.

The effectiveness of esomeprazole 40 mg in patients with persistent symptoms of gastro-oesophageal reflux disease following treatment with a full dose proton pump inhibitor. Int J Clin Pract. Erratum in: Int J Clin Pract. Esomeprazole: a review of its use in the management of acid-related disorders in the US.

Erratum in: Drugs ;62 15 Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection. J Clin Pharm Ther. Epub Apr Request Call Back. Druggist November 17, pm. I am a community pharmacist working in UK. I blog about drugs, health and pharmacy. Esomeprazole vs Omeprazole Proton pump inhibitors PPIs are one of the most commonly prescribed drugs.

In summary, the following will be discussed: What are PPIs? Esomeprazole is also broken down differently by your liver, so it may lead to fewer drug interactions than omeprazole. Some studies indicate that the differences between omeprazole and esomeprazole may offer some advantages to people with certain conditions.

An older study from found that esomeprazole provided more effective control of GERD than omeprazole at the same doses. According to a later study in , esomeprazole offered faster relief than omeprazole in the first week of use. After one week, symptom relief was similar. They cited concerns such as:. The authors analyzed 41 studies on the effectiveness of PPIs.

Until March , Nexium was available only by prescription and at a significantly higher price. However, generic omeprazole may be less expensive than Prilosec OTC. Work with your doctor or pharmacist to decide which PPI is best for you. In addition to cost, consider things like:. A link to possible dementia risk was reported in , but a larger confirmatory study in determined that there was no increased risk of dementia from using PPIs. Many people experience excess acid production when they stop using PPIs.

At the end of the recommended treatment duration, you should taper off of the medication gradually. Work with your doctor to do so. Before taking either medication, talk to your doctor to learn about the risk factors and drug interactions associated with them. Always tell your doctor about all the drugs, herbs, and vitamins you take. Prilosec and Nexium can interact with other medications you might be taking. The U. However, it is important to keep in mind that both esomeprazole and omeprazole may interact with other medications.

Therefore, if you take other medications or have any medical conditions, it is a good idea to talk to your doctor or pharmacist for advice on the best and safest choice for you. Yes, both omeprazole and esomeprazole offer similar symptom relief from heartburn. However, if your heartburn symptoms continue to persist or if you are experiencing any allergic reactions or problems with the medication, it is important to notify your doctor or pharmacist right away.

In this circumstance, it is not recommended to switch medication yourself without prior consultation. Omeprazole is the name of the medicine in Prilosec. In order to take omeprazole, you can take Prilosec or a product like Curist available here at about half the price of Prilosec. Both Prilosec and Curist Omeprazole have the same strength of omeprazole 20 mg , so the symptom relief will be the same. Another important distinction is between prescription RX omeprazole and over-the-counter OTC omeprazole.

Both prescription omeprazole and omeprazole OTC contain the same active ingredient, omeprazole, which effectively reduces stomach acid production.

Prescription omeprazole is used in conjunction with a doctor, and therefore can be used to treat diseases e. Pylori eradication, dyspepsia, Zollinter-Ellison syndrome, etc. Esomeprazole is the name of the medicine in Nexium. To take esomeprazole, you can buy Nexium or a product like Curist available here at about half the price of Nexium. Both Nexium and Curist Esomeprazole have the same strength of esomeprazole 20 mg , so the relief for heartburn and acid reflux is the same.

An important difference is between prescription RX esomeprazole and over-the-counter OTC esomeprazole. Esomeprazole RX and esomeprazole OTC both contain the same medicine, esomeprazole, which treats heartburn symptoms by reducing the production of stomach acid. Prescription esomeprazole is used under the supervision of a doctor, and therefore can be used to treat diseases e.

Pylori eradication, dyspepsia, etc. The over-the-counter versions of esomeprazole and omeprazole are available in local pharmacies as well as stores online like Curist , and do not need a prescription.

At Curist , we develop FDA-approved equivalents to big brands in order to provide the same medicine relief but at half the price of the brands.